Journal: Scientific Reports
Article Title: Therapeutic effect of pH responsive Magainin II modified azithromycin plus curcumin micelles in different depth models of MRSA infection
doi: 10.1038/s41598-025-92384-z
Figure Lengend Snippet: Antibacterial effect of different micellar preparations on mice with pneumonia. ( A ) Real-time imaging observation of lungs treated with varying formulations in vivo. a, for Blank-Ms. B, for free DiR. c, for DiR-Ms. d, for MagII-DiR-Ms. ( B ) Representative images of lung tissue homogenate plate spreading. ( C ) Representative images of pathological changes in lungs by HE staining. ( D – G ) Expression of C5aR1, C5b-9, C3c and NF-κB p65 detected by immunohistochemistry in lungs. ( H – J ) Expression of inflammatory factors in BALF after treatment with different formulations. ( K – M ) Number of inflammatory cells in BALF after treatment with different micelles. Scale bar = 50 μm. Data are presented as mean ± SD ( n = 6), * P < 0.05, ** P < 0.01, **** P < 0.005.
Article Snippet: C5aR1 and NF-κB p65 antibodies were purchased from Boster Co., Ltd. (Wuhan, China).
Techniques: Imaging, In Vivo, Staining, Expressing, Immunohistochemistry